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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: C3 All Species: 15.76
Human Site: S1168 Identified Species: 38.52
UniProt: P01024 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P01024 NP_000055.2 1663 187148 S1168 Q V N S L P G S I T K A G D F
Chimpanzee Pan troglodytes XP_512318 1139 127558 T687 E G I R M N K T V A V R T L D
Rhesus Macaque Macaca mulatta XP_001091921 1500 169769 L1048 G P L L N K F L T T A K D K N
Dog Lupus familis XP_533932 1549 174079 A1095 S L A T N L I A I E A Q V L C
Cat Felis silvestris
Mouse Mus musculus P01027 1663 186464 S1168 Q V N S L P G S I N K A G E Y
Rat Rattus norvegicus P01026 1663 186442 S1168 Q V N S L P G S I N K A G E Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505969 1653 185840 S1161 Q V N S L E N S I K K A G D Y
Chicken Gallus gallus P20740 1473 166336 Q1021 G Y L V S G Y Q K Q L S Y K H
Frog Xenopus laevis NP_001080934 1683 189689 K1152 D N V A V K S K I S K A V D Y
Zebra Danio Brachydanio rerio NP_571318 1651 184738 S1158 A V G S L H E S I R K S V A F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 64.4 79.9 68.7 N.A. 77.1 78.1 N.A. 62.9 21.8 31.7 43.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 65.7 83 80.5 N.A. 87.9 88.5 N.A. 78.2 41 53.1 62.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 6.6 6.6 N.A. 80 80 N.A. 73.3 0 26.6 46.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 26.6 6.6 26.6 N.A. 93.3 93.3 N.A. 80 6.6 53.3 53.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 10 0 0 0 10 0 10 20 50 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 10 0 0 0 0 0 0 0 0 0 0 0 10 30 10 % D
% Glu: 10 0 0 0 0 10 10 0 0 10 0 0 0 20 0 % E
% Phe: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 20 % F
% Gly: 20 10 10 0 0 10 30 0 0 0 0 0 40 0 0 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 10 % H
% Ile: 0 0 10 0 0 0 10 0 70 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 20 10 10 10 10 60 10 0 20 0 % K
% Leu: 0 10 20 10 50 10 0 10 0 0 10 0 0 20 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 40 0 20 10 10 0 0 20 0 0 0 0 10 % N
% Pro: 0 10 0 0 0 30 0 0 0 0 0 0 0 0 0 % P
% Gln: 40 0 0 0 0 0 0 10 0 10 0 10 0 0 0 % Q
% Arg: 0 0 0 10 0 0 0 0 0 10 0 10 0 0 0 % R
% Ser: 10 0 0 50 10 0 10 50 0 10 0 20 0 0 0 % S
% Thr: 0 0 0 10 0 0 0 10 10 20 0 0 10 0 0 % T
% Val: 0 50 10 10 10 0 0 0 10 0 10 0 30 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 10 0 0 0 0 0 10 0 40 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _